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Dehydroepiandrosterone (DHEA) is a 17-ketosteroid that can be reversibly converted to its sulfate ester (DHEA-S) and androstenediol. The adrenal gland secretes both DHEA and DHEA-S, which in turn serve as the precursors for both estrogenic and androgenic steroids. Circulating DHEA is bound by corticosteroid-binding globulin (CBG), albumin, and sex hormone binding globulin. DHEA has been linked to a number of physiological conditions including depression, systemic lupus erythematosus and rheumatoid arthritis.