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Developmental Factors Implicated in Neurodegeneration

Many molecules primarily associated with neuronal development are also implicated in the process of neurodegeneration. Deficits in growth factor regulation, such as BDNF and FGF, may increase vulnerability to age-dependent conditions such as Alzheimer's and Parkinson's disease. In addition, some neurotrophic factors, like VEGF, are up-regulated in response to neuronal injury.