DGK (Diacylglycerol kinase alpha) proteins are type I members of the eukaryocytic diacylglycerol kinase family of enzymes, possessing EF-hand, C1/Cys-rich zinc finger and catalytic domains. DGK-alpha in IL-2-stimulated T cells translocates to the nucleus, promoting proliferation. TCR stimulation, however, promotes anergy. DGK-alpha also participates in VEGF or HGF-mediated motility in endothelial, epithelial, or cancer cells. DGK-gamma is highly enriched in the retina and cerebellar Purkinje cells, and presence of unactivated protein in the nucleus may regulate the cell cycle.