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Produced in the bone marrow, eosinophils differentiate from myeloid precursor cells in response to IL-3, IL-5 and GM-CSF. Eosinophils are polymorphonuclear leukocytes, characterized by eosinophilic granules in the cytoplasm. Eosinophils respond to chemokine attractants secreted by lymphocytes and neutrophils, such as CCL11/eotaxin-1, CCL24/eotaxin-2, and CCL5/RANTES. Recruited eosinophils release the toxic substances contained in their granules to destroy invasive entities and combat infection.