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Growth Hormone (GH) and Receptors

Growth hormone (GH), also known as somatotropin, is a member of a family of growth factors that includes prolactin, placental lactogens, proliferins, and somatolactin. It is synthesized primarily by somatotropes in the anterior pituitary and is stored in secretory granules.

Growth Hormone Receptor (GHR) is type I transmembrane protein expressed on many cell types. Ligation of GHR by Growth Hormone (GH) results in receptor dimerization and activation of the Jak/STAT signaling cascade.