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Hematologic Cancers

Hematologic malignancies (leukemia, lymphoma, and myeloma) are cancers of the blood that arise in the bone marrow or lymphatic system. Generally, these cancers can be characterized by unregulated proliferation and impaired differentiation of transformed myeloid or lymphoid cells. Many blood cancers have been treated by high-dose, non-specific chemotherapies, radiation, bone marrow transplantation, or a combination of these therapies. Recent advances in understanding the biology of hematopoietic progenitor cells, identifying biomarkers, and developing therapeutically relevant monoclonal antibodies have shown promise in detecting and eradicating transformed hematopoietic cells.