Immunoglobulin-Like Domain Transcription Factors

Several transcription factor families contain an immunoglobulin-like DNA-binding domain. The immunoglobulin-like domain consists of a structural core of four beta-strands embedded in an antiparallel curled beta-sheet sandwich with a total of three to five additional strands and binds DNA in the major groove. Transcription factors that contain in immunoglobulin-like domain are involved in many processes, including immunity (NFkB, STAT families), cell cycle and apoptosis (p53), and development and pattern formation (RUNX, TBX families).