Mitotic Checkpoint Serine/Threonine Protein Kinase (Bub)

The Bub1 protein is a serine/threonine kinase that acts in the mitotic spindle checkpoint by recruiting components and promoting kinetochore formation in the inner centromere. Bub1 delays chromosome segregation in response to genotoxic stress. Mutations or the absence of Bub1 can lead to aneuploidy, chromosomal instability, and premature senescence.