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Nitrosylating Molecules

Nitric oxide is a free radical gas that acts as an intracellular signaling molecule. It is widely recognized as a mediator of a variety of normal physiological processes such as vasodilation and immune responses. Nitric oxide is produced by nitric oxide synthase (NOS) in response to molecular cues. In addition to acting as a signaling molecule under normal conditions, high levels of nitric oxide and other reactive nitrogen species (RNS) such as nitrotyrosine and peroxynitrite, together with reactive oxygen species (ROS), can result in oxidative damage to DNA, proteins, and lipids.