NK1 Receptors

NK1R (Neurokinin-1 receptor), gene name TACR1 (tachykinin receptor-1), is a 100 kDa 7-transmembrane glycoprotein receptor for the proinflammatory tachykinin neuropeptide, substance P. NK1R is constitutively or inducibly expressed on a wide variety of cells, including monocytes, macrophages, microglia, lymphocytes, neutrophils, mast cells, and neurons.