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Transcription Factors in the Akt Pathway

Signal transduction often culminates in the activation of transcription factors, a specialized subset of proteins capable of interacting with DNA to either up- or downregulate the transcription of genes. Transcription factor binding is often specific for certain DNA sequences. They are highly regulated with respect to cytoplasmic vs. nuclear localization, stabilization, and post-translational modification. The transcription factors listed below have all been associated with Akt pathway activation, which promotes cell growth, survival, proliferation, autophagy, and metabolism. The activity of these transcription factors is either up- or downregulated by Akt signaling.