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Translation Regulation by the Akt Pathway

Akt signaling is known to promote translation initiation via TOR kinase activation. The molecules listed below are translational regulators that are associated with the Akt pathway. These include eukaryotic initiation factors (eIFs), eIF-binding proteins, and kinases. eIFs form on the ribosome during protein synthesis. Each eIF serves a distinct function during protein synthesis to help attach, assemble, and drive the ribosome along the mRNA. Studies show that eIF activity plays an important role in cell cycle progression, tumorigenesis, embryonic development, nuclear export, and synaptic plasticity.