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Ubiquitin C-terminal Hydrolases (UCH)

Ubiquitin C-terminal hydrolases are a family of cysteine hydrolases that catalyze the hydrolysisof amides, esters and thioesters from the C-terminus of ubiquitin. UCH-L1 is a member of thelow molecular weight UCHs that processes ubiquitin precursors and ubiquitinated proteins togenerate monomeric ubiquitin. The expression of UCH-L1 is highly specific to cells of theneuroendocrine system and their tumors. UCH-L1 variants (Ile93Met) have been linked to Parkinson's disease and may participate in processes critical for neuronal health.