M2c Microglia Activation State Markers
This interactive graphic lists some of the most commonly used M2c microglia markers. Clicking on a marker will take you to the R&D Systems product selection for researching that molecule. Clicking on a molecule that is designated by (novusbio.com) will take you to the Novus Biologicals’ website and their antibody offerings for that protein. Use the buttons below to see markers associated with different activated microglia phenotypes, or view the markers that are used to identify steady-state microglia.
Overview
Microglia, the resident immune cells in the brain, are important for maintenance of brain homeostasis and inflammation induced by pathological insults. Activated microglia display a range of phenotypes that exhibit different functions including inflammation, tissue remodeling, and neuronal protection. M2c microglia, also referred to as the acquired deactivation phenotype, are associated with anti-inflammatory actions, tissue repair, debris scavenging, and iron sequestration. The M2c phenotype is evoked by IL-10, and to lesser extent, by glucocorticoid hormones. These cells display the phenotypic markers Arginase 1 (ARG1), Sphingosine Kinase 1, CD163, and CD206, and secrete IL-10 and TGF-beta.