3C and 3CL Protease Inhibitors Small Molecules and Peptides

3C and 3C-like proteases are cysteine proteases identified in coronaviruses and picornaviruses, such as SARS-CoV, poliovirus and rhinovirus. The active form of these proteases is dimeric, with each monomer contributing a cysteine-histidine catalytic domain to the active site. The individual monomers are inactive without dimerization. 3C and 3CL proteases are essential to the life cycle of the virus, and are key to the proteolytic processing of polyproteins that are translated from viral RNA by ...