103 results for "Jak1" in Products
Jak1 Products
Jak1, Jak 2, and Jak3 belong to the Janus Kinases family of protein tyrosine kinases that couple to cytokine receptors once activated by their corresponding ligands. Activation of Jak family members occurs via phosphorylation at two adjacent tyrosine residues as well as potentially one or more serine residues. Jaks activate members of the STAT family of transcription factors by phosphorylating critical tyrosine regulatory sites.
Jak1 is required for the activation of STAT1 and STAT2 in ...
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2B Monoclonal Clone #413104 |
| Applications: | WB, Simple Western |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2A Monoclonal Clone #452804 |
| Applications: | WB, Simple Western |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #JM75-03 |
| Applications: | IHC, WB, Flow |
![Western Blot: Jak1 Antibody (JM75-03) [NBP2-75547]](https://resources.rndsystems.com/images/products/Jak1-Antibody-JM75-03-Western-Blot-NBP2-75547-img0005.jpg "Western Blot: Jak1 Antibody (JM75-03) [NBP2-75547]")
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Jak1 [p Tyr1022] Antibody](https://resources.rndsystems.com/images/products/nb100-82005_rabbit-polyclonal-jak1-p-tyr1022-antibody-113202594526.jpg "Immunohistochemistry-Paraffin: Jak1 [p Tyr1022] Antibody [NB100-82005] -")
| Reactivity: | Human |
| Source: | HEK293 |
| Accession #: | P23458.2 |
| Applications: | Bioactivity |
| Reactivity: | Human |
| Applications: |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Human |
| Source: | Wheat germ |
| Applications: | WB, ELISA, AP, MA |
| Reactivity: | Human |
| Sensitivity: | 0.094 ng/mL |
| Assay Range: | 0.156-10 ng/mL |
| Applications: | ELISA |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #SR1138 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Applications: | WB |
![Western Blot: Jak1 Overexpression Lysate [NBL1-12093]](https://resources.rndsystems.com/images/products/JAK1-Lysate-Western-Blot-NBL1-12093-img0001.jpg "Western Blot: Jak1 Overexpression Lysate [NBL1-12093]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #7Q1B2 |
| Applications: | WB, ELISA |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #7A5 |
| Applications: | IHC, ELISA |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #23GB2245 |
| Applications: | WB, ICC/IF, Mycoplasma |
Potent JAK inhibitor
| Alternate Names: | Tofacitinib citrate |
| Chemical Name: | (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate |
| Purity: | ≥98% |
Potent and selective JAK1/JAK2 inhibitor; orally bioavailable
| Alternate Names: | INCB018424 |
| Chemical Name: | (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile |
| Purity: | ≥98% |
Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2
| Alternate Names: | INCB 28050 |
| Chemical Name: | 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile |
| Purity: | ≥98% |
JAK1-selective inhibitor
| Chemical Name: | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide |
| Purity: | ≥98% |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |