Ubiquitin Proteasome System Products

R&D Systems provides one of the most complete portfolios of Ubiquitin Proteasome System (UPS) research tools, including high‑quality recombinant ubiquitin proteins, DUBs, ligases, and assay substrates. With over two decades of expertise in protein purification and assay development, we deliver reliable, activity‑verified reagents trusted by UPS and protein degradation researchers worldwide.

Our catalog includes a broad selection of recombinant deubiquitinases (DUBs), such as USP7, and high‑performance substrates, including Ubiquitin‑AMC, Ubiquitin‑rhodamine, and ISG15‑AMC, ideal for enzymatic assays and high‑throughput screening.

For Targeted Protein Degradation (TPD/PROTAC^®) workflows, we offer highly active E3 Ubiquitin Ligases, including VHL and Cereblon (CRBN), as well as Cullin‑Rbx and neddylated Cullin complexes that enable efficient assembly of fully active ligase systems.

Researchers focused on neurodegeneration can rely on our high‑purity Tau, α‑Synuclein, and TDP‑43 proteins, plus industry‑leading USP30 and Parkin (PARK2) enzymes for Alzheimer’s, Parkinson’s, and ALS studies.

Formerly known as Boston Biochem, our Ubiquitin‑Proteasome Group continues to lead the field with rigorously validated UPS reagents and unmatched technical expertise, helping you accelerate discoveries in protein homeostasis and drug development.

Can’t Find Your Protein? Talk to us!

With the sheer number of proteins encompassing the ubiquitin field, we must prioritize which proteins to produce. We may not offer your protein, but it could be in development. Please reach out to our Custom Protein Team to inquire about your protein of interest.

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