Antifungal Compounds Small Molecules and Peptides

Antimycotic Mechanism of Action

The majority of antimycotic compounds, including the azole antifungals such as Fluconazole, the polyene antibiotics such as Amphotericin B, and the allylamine, Terbinafine, exert their effects via disruption of the fungal cell membrane. Azoles are inhibitors of sterol 14α-demethylase, a fungal cytochrome P450 (CYP)-dependent enzyme, which results in depletion of cell membrane ergosterol and impaired membrane fluidity, leading to accumulation of toxic ...