5 results for "Calcitonin R Small Molecules and Peptides" in Products
Calcitonin R Small Molecules and Peptides
The Calcitonin Receptor (CALCR) is a glycosylated 70 kDa seven-transmembrane G protein-coupled receptor that mediates the hypocalcemic effects of the peptide hormone, calcitonin. CALCR activation inhibits osteoclast-mediated bone resorption and enhances renal calcium excretion. CALCR polymorphisms and mutations have been associated with several bone disorders. Alternate splicing of the Calcitonin Receptor results in the deletion of 16 aa in the first cytoplasmic loop or 23 aa in the first extracellular region. Human CALCR shares 70% - 72% aa sequence identity with mouse and rat CACLR.
Synthetic version of amylin (Cat. No. 3418)
| Purity: | ≥95% |
Affects bone formation and resorption
| Purity: | ≥95% |
Non-peptide calcitonin agonist
| Chemical Name: | 5-[1-[(2-Aminophenyl)imino]ethyl]-1,6-dihydroxy-4-methyl-2(1H)-pyridone |
Potent and selective amylin antagonist
| Purity: | ≥95% |
Endogenous calcitonin agonist; inhibits bone resorption
| Purity: | ≥95% |
