Casein Kinase 2 Inhibitors

Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory β-subunits and two catalytic units (α and α′) in a homomeric or heteromeric conformation.

Whilst the α- and α′-subunits are catalytically identical, proteins that regulate CK2, such ...