4 results for "Catechol O-Methyltransferase (COMT) Inhibitors" in Products

Catechol O-Methyltransferase (COMT) Inhibitors

Catechol O-Methyltransferase (COMT) (EC 2.1.1.6) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to a catechol substrate in the presence of magnesium (Mg2+) ions. COMT substrates include dopamine, norepinephrine, epinephrine and levodopa. There are two isoforms of COMT: soluble (S-) COMT and membrane-bound (MB-) COMT.

COMT is ubiquitously expressed, with the highest COMT activity occurring in the liver and kidneys. Notable expression of COMT occurs in kidney ...

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COMT inhibitor

Chemical Name: 3,5-Dinitrocatechol
Purity: ≥99%
COMT inhibitor
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Potent COMT inhibitor; blocks α-synuclein aggregation

Chemical Name: (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
Purity: ≥98%
Potent COMT inhibitor; blocks α-synuclein aggregation
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COMT inhibitor; also inhibits transthyretin aggregation

Alternate Names: Tasmar,Ro 40-7592
Chemical Name: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Purity: ≥98%
COMT inhibitor; also inhibits transthyretin aggregation
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COMT inhibitor

Chemical Name: 5-[3-(2,5-Dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-1,2-benzenediol
Purity: ≥98%
COMT inhibitor
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