4 results for "GAT-1/SLC6A1 Small Molecules and Peptides" in Products
GAT-1/SLC6A1 Small Molecules and Peptides
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl negative channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).
Potent GAT-1 inhibitor; brain penetrant
| Chemical Name: | 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride |
| Purity: | ≥98% |
Selective inhibitor of GAT-1
| Chemical Name: | 1-[2-[bis[4-(Trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride |
| Purity: | ≥98% |
Selective GAT-1 inhibitor
| Chemical Name: | 1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride |
| Purity: | ≥98% |
Selective GAT-1 inhibitor; anticonvulsant
| Chemical Name: | (3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid hydrochloride |
| Purity: | ≥98% |
