3 results for "LIM Kinase 1 Small Molecules and Peptides" in Products
LIM Kinase 1 Small Molecules and Peptides
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.
Potent LIM kinase inhibitor; antitumor
| Alternate Names: | BMS 5 |
| Chemical Name: | N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide |
| Purity: | ≥98% |
Potent and selective LIMK inhibitor; antitumor
| Chemical Name: | N-(2-Hydroxyethyl)-N'-[4,5-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)phenyl]-N-phenylurea |
| Purity: | ≥98% |
Potent LIMK1/2 inhibitor
| Chemical Name: | 4-[[5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]phenol |
| Purity: | ≥98% |
