4 results for "mAChR M2 Antagonists" in Products

mAChR M2 Antagonists

M2 receptors are members of the G-protein-coupled receptor (GPCR) family which are found mostly bound to Gi proteins, generally leading to inhibitory effects. They are one of five muscarinic receptors that act to control the metabotropic functions of acetylcholine (ACh) in the central nervous system (CNS). M2 receptors are densely populated in the heart, airway smooth muscle, the hippocampus and most other brain regions.

Activation of the M2 receptor leads to several responses, including the ...

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Selective M2 antagonist

Chemical Name: N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate
Purity: ≥98%
Selective M2 antagonist
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Selective M2 antagonist

Alternate Names: Otenzepad
Chemical Name: 11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Purity: ≥98%
Selective M2 antagonist
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Potent M2/M4 antagonist

Chemical Name: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Purity: ≥98%
Potent M2/M4 antagonist
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High affinity and selective M2 antagonist

Chemical Name: 11-[[4-[4-(Diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Purity: ≥98%
High affinity and selective M2 antagonist
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