mu Opioid Receptor Antagonists

The μ opioid receptor, (also known as OP₃, MOP, MOR), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and NOP receptors. Three variants of the receptor (designated μ₁, μ₂ and μ₃) have been characterized, arising from the alternative splicing of the this gene.

μ Opioid receptors are distributed throughout the neuraxis (neocortex, thalamus, nucleus accumbens, hippocampus, amygdala) and in the peripheral nervous system ...