IPA 3

Key Product Details

Product Description

IPA 3 is a group I p21-activated kinase (PAK) inhibitor (IC₅₀ = 2.5 μM at PAK1). Targets the autoregulatory mechanism and promotes the inactive conformation of PAKs. Inhibits PAK1-mediated signaling in vivo; potential anti-tumor agent.

Negative Control also available.

Product Specifications for IPA 3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for IPA 3

The following data is based on the product molecular weight 350.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.80 mL	19.02 mL	38.05 mL
3.75 mM	0.76 mL	3.80 mL	7.61 mL
7.5 mM	0.38 mL	1.90 mL	3.80 mL
37.5 mM	0.08 mL	0.38 mL	0.76 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 76 publications citing the usage of this product.

• Wang P21-activated kinase inhibitors FRAX486 and IPA3: inhibition of prostate stromal cell growth and effects on smooth muscle contraction in the human prostate. PLoS One 2016 PMID: 27071060
• Viaud and Peterson An allosteric kinase inhibitor binds the p21-activated kinase (Pak) autoregulatory domain covalently. Mol.Cancer Ther. 2009 PMID: 19723886
• Deacon An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem.Biol. 2008 PMID: 18420139
• Takahashi and Suzuki Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/op18 to Pak1-WAVE2-kinesin complex. Cell.Signal. 2009 PMID: 19162178
• Kumar p21-activated kinases in cancer. Nat.Rev.Cancer 2006 PMID: 16723992

Product Documents for IPA 3