Catalog # Availability Size / Price Qty
IPA 3 | CAS No. 42521-82-4 | PAK Inhibitors
1 Image
Description: Group I PAK inhibitor

Chemical Name: 1,1'-Dithiodi-2-naphthtol

Purity: ≥96%

Product Details
Citations (21)

Biological Activity

IPA 3 is a group I p21-activated kinase (PAK) inhibitor (IC50 = 2.5 μM at PAK1). Targets the autoregulatory mechanism and promotes the inactive conformation of PAKs. Inhibits PAK1-mediated signaling in vivo; potential anti-tumor agent.

Negative Control also available.

Technical Data

Soluble to 75 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for IPA 3

The citations listed below are publications that use Tocris products. Selected citations for IPA 3 include:

21 Citations: Showing 1 - 10

  1. Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling.
    Authors: Zhang Et al.
    Cell Rep  2018;25:598
  2. Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala.
    Authors: Das Et al.
    Sci Rep  2017;7:13930
  3. RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6.
    Authors: Durkin Et al.
    Dev Cell  2017;41:315
  4. PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis.
    Authors: Martin Et al.
    Nat Commun  2016;7:12502
  5. LeftyA decreases Actin Polymerization and Stiffness in Human Endometrial Cancer Cells
    Authors: Salker Et al.
    Scientific Reports  2016;6:29370
  6. 1α,25(OH)2D3 Induces Actin Depolymerization in Endometrial Carcinoma Cells by Targeting RAC1 and PAK1.
    Authors: Zeng Et al.
    Cell Physiol Biochem  2016;40:1455
  7. P21-activated kinase inhibitors FRAX486 and IPA3: inhibition of prostate stromal cell growth and effects on smooth muscle contraction in the human prostate.
    Authors: Wang Et al.
    PLoS One  2016;11:e0153312
  8. Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement.
    Authors: Sorce Et al.
    Oncotarget  2015;6:8872
  9. Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.
    Authors: Imle Et al.
    MBio  2015;6
  10. LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury.
    Authors: Wang and Townes-Anderson
    Nat Neurosci  2015;56:7847
  11. A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation.
    Authors: Oladimeji Et al.
    Am J Physiol Lung Cell Mol Physiol  2015;2:42522
  12. Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis.
    Authors: Mortazavi Et al.
    BMC Cancer  2015;15:381
  13. PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.
    Authors: Pandolfi Et al.
    Blood  2015;126:1118
  14. Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway.
    Authors: Reinardy Et al.
    PLoS One  2015;10:e0139614
  15. Coxsackievirus A9 infects cells via nonacidic multivesicular bodies.
    Authors: Huttunen Et al.
    J Virol  2014;88:5138
  16. Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer.
    Authors: Al-Ejeh Et al.
    J Pharmacol Exp Ther  2014;5:3145
  17. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis.
    Authors: Berger Et al.
    Invest Ophthalmol Vis Sci  2014;28:629
  18. Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase.
    Authors: Molosh Et al.
    Int J Cancer Clin Res  2014;17:1583
  19. Rac1 pathway mediates stretch response in pulmonary alveolar epithelial cells.
    Authors: Dipaolo Et al.
    Nat Commun  2013;305:L141
  20. Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
    Authors: Martin Et al.
    J Clin Invest  2013;123:4449
  21. Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression.
    Authors: Wu Et al.
    Int J Cancer  2010;127:2230


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