Catalog Number: 3622
Chemical Name: 1,1'-Dithiodi-2-naphthtol
Biological Activity
Group I p21-activated kinase (PAK) inhibitor (IC50 = 2.5 μM at PAK1). Targets the autoregulatory mechanism and promotes the inactive conformation of PAKs. Inhibits PAK1-mediated signaling in vivo; potential anti-tumor agent.

Negative Control also available.

Technical Data
  • M.Wt:
    350.45
  • Formula:
    C20H14O2S2
  • Solubility:
    Soluble to 75 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >96%
  • Storage:
    Store at +4°C
  • CAS No:
    42521-82-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.
    Deacon et al.
    Chem.Biol., 2008;15:322
  2. Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/op18 to Pak1-WAVE2-kinesin complex.
    Takahashi and Suzuki
    Cell.Signal., 2009;21:695
  3. An allosteric kinase inhibitor binds the p21-activated kinase (Pak) autoregulatory domain covalently.
    Viaud and Peterson
    Mol.Cancer Ther., 2009;8:2559
  4. p21-activated kinases in cancer.
    Kumar et al.
    Nat.Rev.Cancer, 2006;6:459
  5. P21-activated kinase inhibitors FRAX486 and IPA3: inhibition of prostate stromal cell growth and effects on smooth muscle contraction in the human prostate.
    Wang et al.
    PLoS One, 2016;11:e0153312
Citations:

The citations listed below are publications that use Tocris products. Selected citations for IPA 3 include:

15 Citations: Showing 1 - 10
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  1. LeftyA decreases Actin Polymerization and Stiffness in Human Endometrial Cancer Cells
    Authors: Salker Et al.
    Scientific Reports 2016;6:29370
  2. P21-activated kinase inhibitors FRAX486 and IPA3: inhibition of prostate stromal cell growth and effects on smooth muscle contraction in the human prostate.
    Authors: Wang Et al.
    PLoS One 2016;11:e0153312
  3. Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement.
    Authors: Sorce Et al.
    Oncotarget 2015;6:8872
  4. Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.
    Authors: Imle Et al.
    MBio 2015;6
  5. LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury.
    Authors: Wang and Townes-Anderson
    Nat Neurosci 2015;56:7847
  6. A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation.
    Authors: Oladimeji Et al.
    Am J Physiol Lung Cell Mol Physiol 2015;2:42522
  7. Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis.
    Authors: Mortazavi Et al.
    BMC Cancer 2015;15:381
  8. Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway.
    Authors: Reinardy Et al.
    PLoS One 2015;10:e0139614
  9. Coxsackievirus A9 infects cells via nonacidic multivesicular bodies.
    Authors: Huttunen Et al.
    J Virol 2014;88:5138
  10. Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer.
    Authors: Al-Ejeh Et al.
    J Pharmacol Exp Ther 2014;5:3145
  11. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis.
    Authors: Berger Et al.
    Invest Ophthalmol Vis Sci 2014;28:629
  12. Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase.
    Authors: Molosh Et al.
    Int J Cancer Clin Res 2014;17:1583
  13. Rac1 pathway mediates stretch response in pulmonary alveolar epithelial cells.
    Authors: Dipaolo Et al.
    Nat Commun 2013;305:L141
  14. Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
    Authors: Martin Et al.
    J Clin Invest 2013;123:4449
  15. Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression.
    Authors: Wu Et al.
    Int J Cancer 2010;127:2230
Expand to show all 15 Citations

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