5 results for "Ret Small Molecules and Peptides" in Products
Ret Small Molecules and Peptides
The GDNF family members (GDNF, neurturin, artemin, and persephin) signal through multicomponent receptors that consist of the Ret receptor tyrosine kinase and one of four glycosyl-phosphatidylinositol (GPI)-linked ligand-binding subunits (GFR alpha-1-4). GFR alpha-1, -2, -3 and -4 are the preferred ligand-binding subunits for GDNF, neurturin, artemin, and persephin, respectively. The Ret tyrosine-kinase receptor is encoded by the c-ret proto-oncogene. Human and mouse Ret share 83% amino acid sequence homology.
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
| Alternate Names: | Semaxinib |
| Chemical Name: | 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one |
| Purity: | ≥98% |
Potent RET inhibitor
| Chemical Name: | 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥98% |
Potent and selective RET inhibitor
| Chemical Name: | 6-(2-Hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile |
| Purity: | ≥98% |
Potent VEGFR, PDGFRβ and KIT inhibitor
| Alternate Names: | SU 11248 |
| Chemical Name: | N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioate salt |
| Purity: | ≥98% |
Potent EGFR and VEGFR inhibitor
| Chemical Name: | 6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Purity: | ≥98% |
