5 results for "TRPA1 Blockers Small Molecules and Peptides" in Products
TRPA1 Blockers Small Molecules and Peptides
The ankyrin-like receptor family (TRPA1) is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer. This channel is thought to be indirectly activated by cold; it is often expressed in the same neurons as TRPV1, another thermoTRP, which senses heat.
TRPA1 is sensitive to numerous chemical irritants including cinnamaldehyde, allicin and eugenol. The receptor has been linked to nociceptive transduction and neurogenic inflammation.
Selective TRPA1 blocker
| Chemical Name: | 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide |
| Purity: | ≥98% |
Selective TRPA1 channel blocker
| Alternate Names: | A-079 |
| Chemical Name: | (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime |
| Purity: | ≥98% |
Reversible TRPA1 channel blocker
| Chemical Name: | 4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime |
| Purity: | ≥98% |
Potent and selective TRPA1 antagonist
| Chemical Name: | 1-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one |
| Purity: | ≥98% |
Potent and selective TRPA1 antagonist. Brain penetrant and orally bioavailable
| Chemical Name: | (1R,2R)-2-[(4-Fluorophenyl)amino]-1-(trifluoromethyl)cyclohexanol |
| Purity: | ≥98% |
