Catalog Number: 2896
Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide
Biological Activity
Selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC50 values are 6.2 and 5.3 μM respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or NaV1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo.
Technical Data
  • M.Wt:
    355.39
  • Formula:
    C18H21N5O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    349085-38-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Prostaglandin-induced activation of nociceptive neurons via direct interactions with TRPA1.
    Taylor-Clark et al.
    Mol.Pharmacol., 2008;73:274
  2. TRPA1 mediates formalin-induced pain.
    McNamara et al.
    Proc.Natl.Acad.Sci.USA, 2007;104:13525
Citations:

The citations listed below are publications that use Tocris products. Selected citations for HC 030031 include:

13 Citations: Showing 1 - 10
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  1. Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner.
    Authors: Fernandes Et al.
    Mol Pain 2016;18:7
  2. Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice.
    Authors: Wang Et al.
    World J Gastroenterol 2015;5:16768
  3. Structure of the TRPA1 ion channel suggests regulatory mechanisms.
    Authors: Paulsen Et al.
    Nature 2015;520:511
  4. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
    Authors: Shi Et al.
    Arthritis Res Ther 2015;21:4852
  5. Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
    Authors: Sałat and Filipek
    J Neurosci 2015;16:167
  6. Released lipids regulate transient receptor potential channel (TRP)-dependent oral cancer pain.
    Authors: Ruparel Et al.
    Nat Commun 2015;11:30
  7. Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice.
    Authors: Mueller-Tribbensee Et al.
    PLoS One 2015;10:e0128242
  8. TRPA1 is essential for the vascular response to environmental cold exposure.
    Authors: Aubdool Et al.
    J Zhejiang Univ Sci B 2014;5:5732
  9. Investigating the potential role of TRPA1 in locomotion and cardiovascular control during hypertension.
    Authors: Bodkin Et al.
    Pharmacol Res Perspect 2014;2:e00052
  10. Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels.
    Authors: Nesuashvili Et al.
    Mol Pharmacol 2013;83:1007
  11. Hydrogen sulfide induces hypersensitivity of rat capsaicin-sensitive lung vagal neurons: role of TRPA1 receptors.
    Authors: Hsu Et al.
    Am J Physiol Regul Integr Comp Physiol 2013;305:R769
  12. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors.
    Authors: Gregus Et al.
    Proc Natl Acad Sci U S A 2012;109:6721
  13. TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation.
    Authors: Kunkler Et al.
    Pain 2011;152:38
Expand to show all 13 Citations

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