Selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC50
values are 6.2 and 5.3 μ
M respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or NaV
1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo
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All Tocris products are intended for laboratory research use only.
Prostaglandin-induced activation of nociceptive neurons via direct interactions with TRPA1.
Taylor-Clark et al.
TRPA1 mediates formalin-induced pain.
McNamara et al.
The citations listed below are publications that use Tocris products. Selected citations for HC 030031 include:
Showing Results 1 - 10 of 13