HC 030031

  ( 20 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2896
Chemical Name:2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide
Product Details
Citations (20)
Reviews
Biological Activity
Selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC50 values are 6.2 and 5.3 μM respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or NaV1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo.
Technical Data
  • M.Wt:
    355.39
  • Formula:
    C18H21N5O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    349085-38-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for HC 030031 include:

20 Citations: Showing 1 - 10
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  1. TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p.
    Authors: Berrout Et al.
    Nat Commun  2017;8:947
  2. Effects of ε-viniferin, a dehydrodimer of resveratrol, on transepithelial active ion transport and ion permeability in the rat small and large intestinal mucosa.
    Authors: Karaki Et al.
    Physiol Rep  2016;4
  3. Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner.
    Authors: Fernandes Et al.
    Mol Pain  2016;18:7
  4. Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice.
    Authors: Wang Et al.
    World J Gastroenterol  2015;5:16768
  5. Structure of the TRPA1 ion channel suggests regulatory mechanisms.
    Authors: Paulsen Et al.
    Nature  2015;520:511
  6. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
    Authors: Shi Et al.
    Arthritis Res Ther  2015;21:4852
  7. Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
    Authors: Sałat and Filipek
    J Neurosci  2015;16:167
  8. Released lipids regulate transient receptor potential channel (TRP)-dependent oral cancer pain.
    Authors: Ruparel Et al.
    Nat Commun  2015;11:30
  9. Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice.
    Authors: Mueller-Tribbensee Et al.
    PLoS One  2015;10:e0128242
  10. TRPA1 is essential for the vascular response to environmental cold exposure.
    Authors: Aubdool Et al.
    J Zhejiang Univ Sci B  2014;5:5732
  11. Investigating the potential role of TRPA1 in locomotion and cardiovascular control during hypertension.
    Authors: Bodkin Et al.
    Pharmacol Res Perspect  2014;2:e00052
  12. Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels.
    Authors: Nesuashvili Et al.
    Mol Pharmacol  2013;83:1007
  13. Hydrogen sulfide induces hypersensitivity of rat capsaicin-sensitive lung vagal neurons: role of TRPA1 receptors.
    Authors: Hsu Et al.
    Am J Physiol Regul Integr Comp Physiol  2013;305:R769
  14. Activation of TRPA1 by luminal stimuli induces EP4-mediated anion secretion in human and rat colon.
    Authors: Kaji Et al.
    Am J Physiol Gastrointest Liver Physiol  2012;302:G690
  15. Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice.
    Authors: Liu and Ji
    Neurosci Bull  2012;28:145
  16. Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice.
    Authors: Matsunami Et al.
    Br J Pharmacol  2012;167:917
  17. Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects.
    Authors: Capasso Et al.
    Br J Pharmacol  2012;165:1966
  18. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors.
    Authors: Gregus Et al.
    Proc Natl Acad Sci U S A  2012;109:6721
  19. Effects of luminal thymol on epithelial transport in human and rat colon.
    Authors: Kaji Et al.
    Am J Physiol Gastrointest Liver Physiol  2011;300:G1132
  20. TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation.
    Authors: Kunkler Et al.
    Pain  2011;152:38
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Average Rating: 4 (Based on 1 review)

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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