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Blogs for March 2021

What makes NEW Cultrex™ UltiMatrix BME the matrix for stem cell and organoid cultures?
Monday, March 8, 2021 - 16:41
Lab scientist showing a vial of Cultrex Ultimatrix RGF Basement Membrane Extract (BME), or extracellular matrix (ECM)

Basement Membrane Extract (also referred to as BME, extracellular matrix (ECM), or basement membrane hydrogel) is used globally for culture applications including organoid generation and pluripotent stem cell expansion. While BME is universally utilized as a scaffolding matrix for 2D and 3D cell culture, researchers spend tremendous amounts of effort testing and identifying specific lots of matrix that work for their cells. It can be frustrating and very time consuming.

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Webinar – Arrays in Cancer Research
Tuesday, March 2, 2021 - 14:43

Xin Lu, Ph.D.

Understanding Immunosuppressive Myeloid Cells and Immunotherapy Using Proteome Profiler Antibody Arrays

Jan 29, 2018

Although immune checkpoint blockade is an effective therapeutic intervention for a variety of cancers, it is less effective against metastatic castration-resistant prostate cancer (mCRPC). To address this challenge, Dr. Xin Lu and his colleagues tested the hypothesis that immune checkpoint blockade (ICB) paired with the inhibition of the phosphoinositide 3-kinase (PI 3-K) pathway is a superior therapeutic intervention to ICB alone. Watch this video to see how they used Proteome Profiler™ Antibody Arrays to evaluate signaling in the context of combination therapy.

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