Simple Plex Ultra-Sensitive Assays for Low-Abundance Biomarkers

What are Simple Plex Ultra-Sensitive Assays?

From discovery to clinical research, Simple Plex Ultra-Sensitive Assays simplify biomarker detection while delivering robust, reproducible measurement of low abundant proteins. This advancement enables reliable detection and precise quantification of endogenous biomarkers in plasma and serum samples —without added complexity.

• Ultra sensitivity – Measure biomarkers at endogenous levels with confidence, enabling earlier insights and more precise decision-making.
• Built-in standard curves  – Save time and reduce errors with automated standard curves, ensuring consistent, reproducible results across every run.
• Validated for key sample types  – Get reliable results from the most commonly used sample types including CSF, serum, and plasma so you can focus on discovery without worrying about compatibility or validation.
• Fast results in 2:50 hours – Get actionable data quickly, accelerating your research timelines and improving productivity without sacrificing accuracy. 

High detectability of neurodegeneration biomarkers in healthy plasma, at ultra-low concentrations. Neurodegenerative biomarkers were quantified in plasma samples from healthy donors (age 55+), using the Simple Plex Ultra-Sensitive Assay. The results indicate full detectability and near complete quantifiability of all samples across all assays.

Simple Plex Ultra-Sensitive Assay Technology

How it Works  

• Sample is routed through a microfluidic circuitry, with synchronized release of assay reagents.  
• Sandwich immunoassay occurs within Glass Nano Reactors (GNRs). 

Achieving ultra-sensitive detection

• Assay parameters and microfluidic protocols were systematically optimized to achieve femtogram-level sensitivity.  
• The platform’s high precision minimizes variability at the low end of the standard curve, enabling more reliable quantification of low abundance analytes.

Simple Plex Assays Comparison

Resources

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