ACMSD Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-86480

Novus Biologicals
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all ACMSD Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: KGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPW

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (84%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ACMSD Antibody - BSA Free

ACMSD Antibody - BSA Free Immunohistochemistry-Paraffin: ACMSD Antibody - BSA Free [NBP1-86480]

Immunohistochemistry-Paraffin: ACMSD Antibody - BSA Free [NBP1-86480]

Staining of human liver shows moderate cytoplasmic positivity in hepatocytes.
ACMSD Antibody - BSA Free Immunohistochemistry-Paraffin: ACMSD Antibody - BSA Free [NBP1-86480]

Immunohistochemistry-Paraffin: ACMSD Antibody - BSA Free [NBP1-86480]

Staining of human skeletal muscle shows negative cytoplasmic positivity in myocytes as expected.
ACMSD Antibody - BSA Free Immunohistochemistry-Paraffin: ACMSD Antibody - BSA Free [NBP1-86480]

Immunohistochemistry-Paraffin: ACMSD Antibody - BSA Free [NBP1-86480]

Staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.
ACMSD Antibody - BSA Free Immunohistochemistry-Paraffin: ACMSD Antibody - BSA Free [NBP1-86480]

Immunohistochemistry-Paraffin: ACMSD Antibody - BSA Free [NBP1-86480]

Staining of human kidney shows strong cytoplasmic positivity in cells in tubules.
ACMSD Antibody - BSA Free Western Blot: ACMSD Antibody - BSA Free [NBP1-86480]

Western Blot: ACMSD Antibody - BSA Free [NBP1-86480]

Analysis in control (vector only transfected HEK293T lysate) and ACMSD over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells).
ACMSD Antibody - BSA Free Immunohistochemistry-Paraffin: ACMSD Antibody - BSA Free [NBP1-86480]

Immunohistochemistry-Paraffin: ACMSD Antibody - BSA Free [NBP1-86480]

Analysis in human kidney and skeletal muscle tissues Corresponding ACMSD RNA-seq data are presented for the same tissues.

Applications for ACMSD Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ACMSD

The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM]

Alternate Names

aminocarboxymuconate semialdehyde decarboxylase, EC 4.1.1.45,2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, Picolinate carboxylase

Gene Symbol

ACMSD

Additional ACMSD Products

Product Documents for ACMSD Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for ACMSD Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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