Als2 Antibody

Novus Biologicals | Catalog # NB100-885

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Predicted:

Bovine (100%), Canine (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Cited:

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all Als2 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence LKACYYQIQREKLN corresponding to C-Terminus according to NP_065970.2.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 22982304).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Als2 Antibody

Immunohistochemistry: Als2 Antibody [NB100-885]

Immunohistochemistry: Als2 Antibody [NB100-885]

Immunohistochemistry: Als2 Antibody [NB100-885] - IHC staining of Als2 in paraffin embedded Human Cortex using NB100-885 at 3.8ug/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for Als2 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

3 - 5 ug/ml

Peptide ELISA

Detection limit 1:8000
Application Notes
WB: No signal obtained yet but low background observed in human brain extracts at upto 1 ug/ml. IHC-P: Human cortex shows pixulate cytoplasm staining in some neuronal cells.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Als2

Defects in ALS2, or Alsin, are the cause of amyotrophic lateral sclerosis 2 (ALS2), juvenile primary lateral sclerosis (JPLS), and infantile-onset ascending spastic paralysis (IAHSP). ALS2 is a neurodegenerative disorder which is closely related to but clinically distinct from juvenile primary lateral sclerosis. It is a progressive paralytic disorder which results from dysfunction of the motor systems comprising the upper motor neurons of the motor cortex and lower motor neurons of the brain stem and spinal cord. JPLS is a neurodegenerative disorder which is closely related to but clinically distinct from amyotrophic lateral sclerosis. It is a progressive paralytic disorder which results from dysfunction of the upper motor neurons of the motor cortex while the lower neurons are unaffected. IAHSP is characterized by progressive spasticity and weakness of limbs.

Alternate Names

ALS2CR6, alsin, ALSJ, amyotrophic lateral sclerosis 2 (juvenile), amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 6, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis 2 protein, FLJ31851, IAHSP, KIAA1563, MGC87187, PLSJ

Entrez Gene IDs

57679 (Human)

Gene Symbol

ALS2

UniProt

Q96Q42 (Human)

Additional Als2 Products

Product Documents for Als2 Antibody

Certificate of Analysis

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Product Specific Notices for Als2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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