Cultrex Extracellular Matrix (ECM) Proteins provide a defined substrate for cell adhesion in cell cultures. Many proteins of the ECM interact with cells via cell surface integrin family receptors. The resulting focal contacts are important in maintaining tissue architecture and for supporting a variety of cellular processes. ECM molecule/integrin binding may initiate a complex network of signal transduction cascades that play an important role in cell spreading, migration, proliferation, and differentiation during embryogenesis, wound healing, and tumor development.
To accommodate a variety of different models, we have developed a full range of extracellular matrix component proteins including Laminin I, Collagen I, Collagen IV, and Vitronectin. These include purified proteins that have been qualified for 3-D or stem cell cultures.
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Protein |
Description |
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Used for coating of tissue culture surfaces to promote cell attachment and proliferation and to study its effects on cell behavior. |
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Major structural component of extracellular matrices found in connective tissue and internal organs, used to promote cell attachment, growth, differentiation, migration, and tissue morphogenesis during development. The 5 mg/ml concentration is very viscous for researchers wanting a thicker Collagen. |
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Diluted to a lower concentration (3 mg/ml); it is less viscous and easier to handle. A major structural component of extracellular matrices found in connective tissue and internal organs, but most prevalent in dermis, tendons, and bone. It promotes cell attachment, proliferation, differentiation, migration, and tissue morphogenesis. |
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The 3-D Culture Matrix Collagen I may be used as a gel on which to grow cells or a media additive alone or in concert with other basement membrane components to study 3D cellular growth and differentiation in vitro. |
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A purified basement membrane protein that has been developed, produced and qualified specifically for cell culture studies where the presence of pathogens may cause concern. Stem cell qualified option available. |
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3-D Culture Matrix Mouse Laminin I may be used as a gel on which to grow cells, as a media additive alone or in concert with other basement membrane components, or to study cellular growth and differentiation in three dimensions in vitro. |
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Vitronectin is a large glycoprotein found in blood and the ECM. Vitronectin contains multiple binding sites for a variety of structures. |