Cultrex 3-D Culture Matrix Rat Collagen I
Cultrex 3-D Culture Matrix Rat Collagen I Summary
Why Use Cultrex 3-D Culture Matrix Rat Collagen I?
Cultrex 3-D Culture Matrix Collagen I is purified from rat tail tendons and is provided at a high concentration that is capable of polymerizing to form a hydrogel. Collagen I is the major structural component of extracellular matrices (ECM) found in connective tissue and internal organs, but is most prevalent in the dermis, tendons, and bone. It is a 300 kDa molecule composed of two alpha1(I) chains and one alpha2(I) chain that spontaneously forms a triple helix scaffold at a neutral pH and 37̊ C. This phenomenon can be exploited to promote cell attachment, growth, differentiation, migration, and tissue morphogenesis during development. To provide the most standardized Collagen I for use in 3-D cultures, a special process is employed to provide material at a standard concentration of approximately 5 mg/mL. This material is then incorporated in a 3-D culture to validate efficacy.Cultrex 3-D Culture Matrix Collagen I is a purified stromal ECM protein that has been developed, produced and qualified specifically for use in 3-D culture studies. 3-D Culture Matrix Collagen I may also be used to supplement customized hydrogel or medium formulations for cell culture.
Cell Attachment - Tested for the ability to Supports cell attachment and spreading of MG63 human osteosarcoma cells.
For research use only. Not for diagnositic use.
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