CLCC1 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-82792

Novus Biologicals
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all CLCC1 Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: HDDDWIDPTDMLNYDAASGTMRKSQAKYGISGEKDVSPDLSCADEISECYHKLDSLTYKIDECEKKKREDYESQSNPVFRRYLNKILIEAGKLGLL

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (81%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CLCC1 Antibody - BSA Free

Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792]

Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792]

Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792] - Staining of human cerebellum, endometrium, kidney and testis using Anti-CLCC1 antibody NBP1-82792 (A) shows similar protein distribution across tissues to independent antibody NBP1-82793 (B).
Immunocytochemistry/ Immunofluorescence: CLCC1 Antibody [NBP1-82792]

Immunocytochemistry/ Immunofluorescence: CLCC1 Antibody [NBP1-82792]

Immunocytochemistry/Immunofluorescence: CLCC1 Antibody [NBP1-82792] - Immunofluorescent staining of human cell line U-251 MG shows localization to endoplasmic reticulum & vesicles.
Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792]

Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792]

Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792] - Staining of human testis shows strong cytoplasmic positivity in Leydig cells.
Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792]

Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792]

Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792] - Staining of human cerebellum shows weak positivity in neuronal processes.
Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792]

Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792]

Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792] - Staining of human endometrium shows strong cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792]

Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792]

Immunohistochemistry-Paraffin: CLCC1 Antibody [NBP1-82792] - Staining of human kidney shows moderate cytoplasmic positivity in cells in tubules.

Applications for CLCC1 Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF, Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CLCC1

Chloride channels (CLCs) regulate cellular traffic of chloride ions, a critical component of all living cells. CLCs are involved in membrane potential stabilization, signal transduction, cell volume regulation and organic solute transport. CLCC1 (Chloride channel CLIC-like protein 1), also known as MCLC (Mid-1-related chloride channel) or KIAA0761, is a 551 amino acid multi-pass membrane protein that belongs to the chloride channel MCLC family. CLCC1 is related to the Saccharomyces cerevisiaeprotein Mid-1 and is believed to function as an intracellular chloride channel that is expressed in lung, brain, muscle, liver and testis. Localizing to intracellular compartments such as the Golgi apparatus, the endoplasmic reticulum (ER) and the nuclear envelope, CLCC1 is expressed as four isoforms due to alternative splicing events, namely hMCLC-1, hMCLC-2, hMCLC-3 and hMCLC-4.

Alternate Names

chloride channel CLIC-like 1, KIAA0761, MCLCchloride channel CLIC-like protein 1, Mid1-related chloride channel, Mid-1-related chloride channel 1, Mid-1-related chloride channel protein 1

Gene Symbol

CLCC1

Additional CLCC1 Products

Product Documents for CLCC1 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for CLCC1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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