Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # OTI4E7

Format

Azide and BSA Free
View all COPS6 Primary Antibodies »

Product Specifications

Immunogen

Human recombinant protein fragment corresponding to amino acids 58-327 of human COPS6(NP_006824) produced in E.coli.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Theoretical MW

36 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for COPS6 Antibody (OTI4E7) - Azide and BSA Free

Western Blot: COPS6 Antibody (OTI4E7)Azide and BSA Free [NBP2-71648]

Western Blot: COPS6 Antibody (OTI4E7)Azide and BSA Free [NBP2-71648]

Western Blot: COPS6 Antibody (OTI4E7) - Azide and BSA Free [NBP2-71648] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY COPS6.
Immunocytochemistry/ Immunofluorescence: COPS6 Antibody (OTI4E7) - Azide and BSA Free [NBP2-71648]

Immunocytochemistry/ Immunofluorescence: COPS6 Antibody (OTI4E7) - Azide and BSA Free [NBP2-71648]

Immunocytochemistry/Immunofluorescence: COPS6 Antibody (OTI4E7) - Azide and BSA Free [NBP2-71648] - Analysis of COS7 cells transiently transfected by pCMV6-ENTRY COPS6.
Immunohistochemistry: COPS6 Antibody (OTI4E7) - Azide and BSA Free [NBP2-71648]

Immunohistochemistry: COPS6 Antibody (OTI4E7) - Azide and BSA Free [NBP2-71648]

Immunohistochemistry: COPS6 Antibody (OTI4E7) - Azide and BSA Free [NBP2-71648] - Analysis of Human Kidney tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
Immunohistochemistry: COPS6 Antibody (OTI4E7) - Azide and BSA Free [NBP2-71648]

Immunohistochemistry: COPS6 Antibody (OTI4E7) - Azide and BSA Free [NBP2-71648]

Immunohistochemistry: COPS6 Antibody (OTI4E7) - Azide and BSA Free [NBP2-71648] - Analysis of Carcinoma of Human thyroid tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)

Applications for COPS6 Antibody (OTI4E7) - Azide and BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100

Immunohistochemistry

1:150

Western Blot

1:2000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Reconstitution

we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process.

Formulation

Lyophilized from PBS (pH 7.3) with 8% Trehalose

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: COPS6

COPS6 is encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq]

Alternate Names

BMP2B, BMP2B1, BMP4, COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis), COP9 signalosome complex subunit 6, CSN6COP9 subunit 6 (MOV34 homolog, 34 kD), H_NH0506M12.12, hVIP, JAB1-containing signalosome subunit 6, MOFC11, MOV34 homolog, MOV34 homolog, 34 kD, MOV34-34KD, SGN6, Signalosome subunit 6, Vpr-interacting protein

Gene Symbol

COPS6

Additional COPS6 Products

Product Documents for COPS6 Antibody (OTI4E7) - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for COPS6 Antibody (OTI4E7) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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