EPB41L3 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-89372

Novus Biologicals
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all EPB41L3 Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: TESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEGAKEEGGEEVAKAVLE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for EPB41L3 Antibody - BSA Free

EPB41L3 Antibody - BSA Free Immunohistochemistry-Paraffin: EPB41L3 Antibody - BSA Free [NBP1-89372]

Immunohistochemistry-Paraffin: EPB41L3 Antibody - BSA Free [NBP1-89372]

Analysis in human testis and skeletal muscle tissues using NBP1-89372 antibody. Corresponding EPB41L3 RNA-seq data are presented for the same tissues.
EPB41L3 Antibody - BSA Free Immunohistochemistry-Paraffin: EPB41L3 Antibody - BSA Free [NBP1-89372]

Immunohistochemistry-Paraffin: EPB41L3 Antibody - BSA Free [NBP1-89372]

Staining of human testis shows moderate cytoplasmic and membranous positivity in cells in seminiferous ducts.
EPB41L3 Antibody - BSA Free Immunohistochemistry-Paraffin: EPB41L3 Antibody - BSA Free [NBP1-89372]

Immunohistochemistry-Paraffin: EPB41L3 Antibody - BSA Free [NBP1-89372]

Staining of human skeletal muscle shows no positivity in myocytes as expected.
Immunohistochemistry-Paraffin: EPB41L3 Antibody [NBP1-89372]

Immunohistochemistry-Paraffin: EPB41L3 Antibody [NBP1-89372]

Immunohistochemistry-Paraffin: EPB41L3 Antibody [NBP1-89372] - Staining of human gastrointestinal shows moderate to strong cytoplasmic and membranous positivity in glandular cells.
EPB41L3 Antibody - BSA Free Immunohistochemistry-Paraffin: EPB41L3 Antibody - BSA Free [NBP1-89372]

Immunohistochemistry-Paraffin: EPB41L3 Antibody - BSA Free [NBP1-89372]

Staining of human kidney shows moderate to strong membranous positivity in cells in tubules.
EPB41L3 Antibody - BSA Free Western Blot: EPB41L3 Antibody - BSA Free [NBP1-89372]

Western Blot: EPB41L3 Antibody - BSA Free [NBP1-89372]

Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11
Lane 2: Human cell line RT-4
Lane 3: Human cell line U-251MG sp
EPB41L3 Antibody - BSA Free

ICC/IF: EPB41L3 Antibody [NBP1-89372] -

ICC/IF: EPB41L3 Antibody [NBP1-89372] - Staining of human cell line U-2 OS shows localization to plasma membrane.

Applications for EPB41L3 Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:2500 - 1:5000

Immunohistochemistry-Paraffin

1:2500 - 1:5000

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF, Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: EPB41L3

Band 4.1-like protein 3 (EPB41L3) is a critical growth regulator in the pathogenesis of meningiomas. EPB41L3 is highly Expressed in the brain, with lower levels found in the kidneys, intestines, and testis.

EPB41L3 is a member of a family of similar proteins whose expression is frequently lost in a variety of human tumors, including meningiomas, non-small-cell lung cancers, and breast carcinomas. It is also frequently down-regulated in human clinical prostate cancer. Studies have shown that Protein 4.1B normally triggers death in metastatic cells, thereby preventing cancer from spreading. A clinical test for Protein 4.1B activity could be useful in assessing the metastatic potential of prostate cancers. Therefore, EPB41L3 antibodies may be very useful for cancer research.

Alternate Names

4.1BFLJ37633, DAL1DAL-1,, Differentially expressed in adenocarcinoma of the lung protein 1, erythrocyte membrane protein band 4.1-like 3, KIAA0987band 4.1-like protein 3

Gene Symbol

EPB41L3

Additional EPB41L3 Products

Product Documents for EPB41L3 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for EPB41L3 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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