ER alpha/NR3A1 Antibody (S21-V)

Name: ER alpha/NR3A1 Antibody (S21-V)
Brand: Novus Biologicals
SKU: NBP1-30153
Price: 439 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-30153

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S21-V

View all ER alpha/NR3A1 Primary Antibodies »

Product Specifications

Immunogen

Peptide derived from C-terminal sequence of human ER alpha/NR3A1. Antibody recognizes the epitope between Gln580 - Thr594.

Epitope

Gln580 - Thr594

Specificity

This antibody is specific for the C terminus of Estrogen Receptor.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

This antibody is immunoaffinity purified with immunogenic peptide as a ligand.

Scientific Data Images for ER alpha/NR3A1 Antibody (S21-V)

Immunohistochemistry-Paraffin: ER alpha/NR3A1 Antibody (S21-V) [NBP1-30153]

Immunohistochemistry-Paraffin: Estrogen Receptor Antibody (S21-V) [NBP1-30153] - human of breast tumor tissue stained with Estrogen Receptor antibody shows strong positive nuclear immunostaining.

Applications for ER alpha/NR3A1 Antibody (S21-V)

Application

Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:100-200

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

20mM Tris-HCl (pH 8.0) and 20mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: ER alpha/NR3A1

The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ER mRNA transcripts, which differ primarily in their 5-prime untranslated regions. Two isoforms of the human ER, ERA and ER-beta, occur, each with distinct tissue and cell patterns of expression. Pelletier and El-Alfy (2000) studied the immunocytochemical localization of ESRA and ESRB in human reproductive tissues. In the ovary, ERB immunoreactivity was found in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, interstitial gland, and germinal epithelium cells. Nuclear staining for ERA occurred in thecal, interstitial gland, and germinal epithelium cells. In the uterus, strong ERA immunoreactivity was detected in nuclei of epithelial, stromal, and muscle cells.

Long Name

Estrogen Receptor alpha

Alternate Names

ESR1, NR3A1

Entrez Gene IDs

2099 (Human)

Gene Symbol

ESR1

UniProt

P03372

Additional ER alpha/NR3A1 Products

Product Documents for ER alpha/NR3A1 Antibody (S21-V)

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Certificate of Analysis

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Product Specific Notices for ER alpha/NR3A1 Antibody (S21-V)

This antibody is immunoaffinity purified with immunogenic peptide as a ligand.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Cancer Biomarkers

Nuclear Hormone Receptors and Regulators

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