GNAQ Antibody

Novus Biologicals | Catalog # NBP1-72047

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine

Predicted:

Bovine (100%), Canine (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all GNAQ Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-NDLDRVADPAYLPT corresponding to internal region according to NP_002063.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for GNAQ Antibody

Western Blot: GNAQ Antibody [NBP1-72047]

Western Blot: GNAQ Antibody [NBP1-72047]

Western Blot: GNAQ Antibody [NBP1-72047] - Staining of Pig Colon (A) and Pig Spleen (B) lysates (35 ug protein in RIPA buffer). Antibody at 0.1 ug/mL. Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: GNAQ Antibody [NBP1-72047]

Immunohistochemistry-Paraffin: GNAQ Antibody [NBP1-72047]

Immunohistochemistry-Paraffin: GNAQ Antibody [NBP1-72047] - Staining of paraffin embedded Human Kidney. Antibody at 5 ug/mL. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Western Blot: GNAQ Antibody [NBP1-72047]

Western Blot: GNAQ Antibody [NBP1-72047]

Western Blot: GNAQ Antibody [NBP1-72047] - Staining of Mouse (A) and Rat (B) Testis lysates (35 ug protein in RIPA buffer). Antibody at 0.1 ug/mL. Primary incubation was 1 hour. Detected by chemiluminescence.
Western Blot: GNAQ Antibody [NBP1-72047]

Western Blot: GNAQ Antibody [NBP1-72047]

Western Blot: GNAQ Antibody [NBP1-72047] - Staining of Human Peripheral Blood Lymphocytes lysate (35 ug protein in RIPA buffer). Antibody at 0.1 ug/mL. Primary incubation was 1 hour. Detected by chemiluminescence

Applications for GNAQ Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5 ug/mL

Peptide ELISA

Detection limit 1:64000

Western Blot

0.1 - 0.3 ug/mL
Application Notes
WB: Approx. 40 kDa band observed in human, mouse and rat testis lysates, in porcine colon and spleen lysates and in lysates of human peripheral blood mononucleocytes (calculated MW of 42.1 kDa band according to human NP_002063.2 and to rat NP_112298.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GNAQ

GNAQ, also known as Guanine nucleotide-binding protein G(q) subunit alpha, is a 359 amino acid that is 42 kDa, with subcellular nucleus location, expressed in ovary, prostate, testis and colon tissue; necessary modulator or transducer in various transmembrane signaling systems; controls B-cell selection and survival, needed to prevent B-cell-dependent autoimmunity; and also regulates chemotaxis of BM-derived neutrophils and dendritic cells. Studies on this protein have shown a relationship with the following diseases and disorders: bleeding diathesis due to gnaq deficiency, cellular blue nevus, pertussis, melanoma, acanthocytosis, fainting, polycystic ovary syndrome, trypanosomiasis, gitelman syndrome chorea, thyroid nodule, huntington's disease, thyroiditis, chagas disease, alzheimer's disease, melanoma metastasis, vasculitis, neuronitis, erythroleukemia, and heart failure. GNAQ has also shown an interaction with AGTR1, CXCR5, CRHR1, GALR2, HTR2C, and over 100 other interacting proteins in many different pathways including calcium signaling pathway, vascular smooth muscle contraction, gap junction, long-term potentiation, glutamatergic synapse, GPCR downstream signaling, hemostasis, gastrin-CREB signalling pathway via PKC and MAPK, signaling by GPCR, signal amplification.

Alternate Names

GAQG-ALPHA-q, guanine nucleotide binding protein (G protein), q polypeptide, Guanine nucleotide-binding protein alpha-q, guanine nucleotide-binding protein G(q) subunit alpha

Entrez Gene IDs

2776 (Human); 14682 (Mouse); 81666 (Rat)

Gene Symbol

GNAQ

UniProt

NP_002063.2 (Human)

Additional GNAQ Products

Product Documents for GNAQ Antibody

Certificate of Analysis

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Product Specific Notices for GNAQ Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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