Human A20/TNFAIP3 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: A20/TNFAIP3

A20, also called TNF alpha -induced protein 3 (TNFAIP3), is a cytoplasmic zinc finger protein that inhibits NF kappa B activity and tumor necrosis factor-mediated programmed cell death. The protein interacts with NAF1 and inhibits TNF-induced NF kappa B-dependent gene expression by interfering with RIP- or TRAF2-mediated transactivation signaling. A20 contains an N-terminal domain which has deubiquitinating enzyme activity and removes ubiquitin chains from receptor-interacting protein (RIP), thus mediating distinct regulatory effects in the down-regulation of NF kappa B signaling.

Product Datasheets

Related Research Areas

• Cancer Stem Cell Markers
• Deubiquitinating Enzymes (DUBs)
• E3 Ubiquitin Ligases
• Immunoglobulin-Like Domain Transcription Factors
• NFkB Pathway
• TNF Superfamily Regulators
• Ubiquitin-related Molecules in the Akt Pathway