Human BMP-7 Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB3542N Datasheet / COA / SDS

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FAB3542N-100UG

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All BMP-7 Antibodies

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Human BMP-7 Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human BMP-7 in ELISAs. In ELISAs, this antibody shows approximately 25-50% cross-reactivity with recombinant human (rh) BMP‑6 and no cross-reactivity with rhBMP-2, -3, -4, -5, or -8.

Source

Monoclonal Mouse IgG1 Clone # 164313

Purification

Protein A or G purified

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human BMP‑7
Arg292-His431
Accession # P18075

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Neutralization

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: BMP-7

BMP-7, or osteogenic protein 1 (OP-1), is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor beta (TGF-beta ) superfamily. BMPs regulate cartilage and bone formation, embryogenesis and morphogenesis of various tissues and organs, and growth, differentiation, chemotaxis and apoptosis of various cell types. Biologically active BMP-7 is a disulfide-linked homodimer. Cellular responses to BMP-7 have been shown to be mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors.

Long Name

Bone Morphogenetic Protein 7

Entrez Gene IDs

655 (Human); 12162 (Mouse); 85272 (Rat)

Alternate Names

BMP7; BMP-7; bone morphogenetic protein 7; Eptotermin alfa; OP-1; OP-1OP1; Osteogenic protein 1