Human CD155/PVR Alexa Fluor® 594-conjugated Antibody

Catalog # Availability Size / Price Qty
Product Details
Supplemental Products

Human CD155/PVR Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity
Detects human CD155/PVR in direct ELISAs and Western blots.
Monoclonal Mouse IgG1 Clone # 300907
Mouse myeloma cell line NS0-derived recombinant human CD155/PVR
Accession # AAH15542
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)


Recommended Concentration
Flow Cytometry
0.25-1 µg/106 cells
U937 human histiocytic lymphoma cell line and HUVEC human umbilical vein endothelial cells

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: CD155/PVR

CD155 [also known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5)] is a 70 kDa type I transmembrane (TM) glycoprotein that is a member of the nectin-like (Necl) family of nectin-related molecules (1). Like nectins, Necl molecules are Ig superfamily members that contain three Ig-like extracellular domains, a TM segment, and a cytoplasmic tail. Unlike nectins, Necl molecules cannot interact with cytoplasmic afadin (1). While Nectins serve as cell adhesion molecules, the actual functions of most Necls are yet-to-be determined. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells (2, 3). The full-length (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N-terminal V-type and two C2-type Ig-like domains (2, 3). The V-type domain mediates polio virus binding (4). Three other isoforms exist, all of which retain the Ig-like domains. CD155δ is transmembrane with a shortened cytoplasmic tail of 25 aa. CD155 beta (352 aa) and CD155 gamma (344 aa) are 60‑65 kDa soluble forms that show removal of the TM segment and surrounding amino acids (2, 5). The soluble forms will bind the polio virus (due to the presence of the V-type Ig domain) but afford no protection against polio infection because of low circulating levels (5). CD155 has been demonstrated to bind vitronectin, nectin-3, and DNAM-1 (6‑8). DNAM-1 binding promotes monocyte migration and NK cell killing. CD155 is expressed in all normal tissues and is highly expressed in tumor cells of epithelial and neuronal origin.

  1. Takai, Y. et al. (2003) Cancer Sci. 94:655.
  2. Mendelsohn, C.L. et al. (1989) Cell 56:855.
  3. Koike, H. et al. (1990) EMBO J. 9:3217.
  4. Koike, S. et al. (1991) Proc. Natl. Acad. Sci. USA 88:4104.
  5. Baury, B. et al. (2003) Biochem. Biophys. Res. Commun. 309:175.
  6. Mueller, S. and E. Wimmer (2003) J. Biol. Chem. 278:31251.
  7. Reymond, N. et al. (2004) J. Exp. Med. 199:1331.
  8. Lange, R. et al. (2001) Virology 285:218.
Long Name
Poliovirus Receptor
Entrez Gene IDs
5817 (Human); 52118 (Mouse); 25066 (Rat); 102136444 (Cynomolgus Monkey); 712851 (Rhesus Macaque)
Alternate Names
CD155 antigen; CD155; HVED; NECL5; Necl-5; nectin-like 5; Nectin-like protein 5; poliovirus receptor; PVR; PVS; PVSFLJ25946; Tage4

Product Datasheets


No product specific FAQs exist for this product, however you may

View all Antibody FAQs

Reviews for Human CD155/PVR Alexa Fluor® 594-conjugated Antibody

There are currently no reviews for this product. Be the first to review Human CD155/PVR Alexa Fluor® 594-conjugated Antibody and earn rewards!

Have you used Human CD155/PVR Alexa Fluor® 594-conjugated Antibody?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review