Human CD20 (Research Grade Ocrelizumab Biosimilar) Alexa Fluor® 532-conjugated Antibody

Catalog #: FAB11595X Datasheet / COA / SDS

Recombinant Monoclonal Antibody For Research Use Only

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FAB11595X-100UG

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All CD20 Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CD20 (Research Grade Ocrelizumab Biosimilar) Alexa Fluor® 532-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Stains hCD20-eGFP transfected HEK293 cells in flow cytometry.

Source

Monoclonal Human IgG1 Clone # Hu202

Purification

Protein A or G purified

Immunogen

Human CD20

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 532 (Excitation= 534 nm, Emission= 553 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CD20

Ocrelizumab is an anti-human CD20 antibody used for the treatment of advanced or relapsing multiple sclerosis. It is a humanized recombinant anti human CD20 antibody, and is used to specifically deplete B-cells. A proposed pharmacological mechanism of action is that the antibody most likely binds to the B-cell surface CD20 resulting in antibody-dependent cellular cytotoxicity and complement-mediated cell lysis, but does not impact B-cell reconstitution and preexisting humoral immunity.

Long Name

Cluster of Differentiation 20

Entrez Gene IDs

931 (Human); 12482 (Mouse); 25316 (Rat); 485430 (Canine); 102118491 (Cynomolgus Monkey)

Alternate Names

B1; B-lymphocyte antigen CD20; B-lymphocyte cell-surface antigen B1; B-lymphocyte surface antigen B1; Bp35; Bp35MGC3969; CD20 antigen; CD20 receptor; CD20; CD20S7; CVID5; LEU-16; Leukocyte surface antigen Leu-16; Ly-44; Membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains, subfamily A, member 1; MS4A1; MS4A2; S7