Human CRBN Alexa Fluor® 488-conjugated Antibody

Catalog #: FAB9574G Datasheet / COA / SDS

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FAB9574G-100UG

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Human CRBN Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human CRBN in immunocytochemistry and immunohistochemistry.

Source

Monoclonal Mouse IgG2b Clone # 978015

Purification

Protein A or G purified

Immunogen

Synthetic peptide Human CRBN
Accession # Q96SW2

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CRBN

Cerbeblon (CRBN) is a substrate recognition component of an E3 protein ligase complex which mediates ubiquitination and proteasomal degradation of target proteins. In embryonic development, degradation of regulatory proteins is required for normal limb outgrowth. Thalidomide, a teratogenic drug prescribed to pregnant women in the 1950s, binds to CRBN in the E3 protein ligase complex. Despite its teratogenic effect, CRBN is used to treat multiple myeloma and complications of leprosy. Widely expressed, CRBN may play a role in memory and learning by regulating assembly and surface expression of large-conductance calcium-activated potassium channels in hippocampal neurons. Mutations in the CRBN gene is linked to the Mental Retardation, Autosomal Recessive2a (MR2A) form of mental retardation.

Long Name

Cereblon

Entrez Gene IDs

51185 (Human); 58799 (Mouse); 297498 (Rat)

Alternate Names

Cereblon; CRBN; DKFZp781K0715; MGC27358; MRT2; MRT2A; non-syndromic, autosomal recessive, 2A; protein cereblon; Protein X 0001