203 results for "CRBN" in 产品
CRBN Products
Modulates cell surface expression of KCNT1 . May be involved in memory and learning
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | KO, WB, ICC/IF, Simple Western, Mycoplasma, + 1 More |
![Immunocytochemistry/ Immunofluorescence: CRBN Antibody [NBP1-91810]](https://resources.rndsystems.com/images/products/CRBN-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-91810-img0027.jpg "Immunocytochemistry/ Immunofluorescence: CRBN Antibody [NBP1-91810]")
| Reactivity: | Human |
| Source: | Sf 21 (baculovirus) |
| Accession #: | Q16531.1, Q96SW2.1 |
| Applications: | Bioactivity |
| Reactivity: | Human |
| Source: | Sf 21 (baculovirus) |
| Accession #: | Q13619.3 (CUL4A); P62877.1 (RBX1); Q16531.1 (DDB1), Q96SW2.1 (CRBN) |
| Applications: | Bioactivity |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
| Reactivity: | Human |
| Details: | Mouse IgG Polyclonal |
| Applications: | IHC, WB, IP |
![Western Blot: CRBN Antibody [H00051185-B01P]](https://resources.rndsystems.com/images/products/CRBN-Antibody-Western-Blot-H00051185-B01P-img0002.jpg "Western Blot: CRBN Antibody [H00051185-B01P]")
| Reactivity: | Human |
| Source: | Wheat germ |
| Applications: | WB, ELISA, AP, MA |
![SDS-PAGE: Recombinant Human CRBN GST (N-Term) Protein [H00051185-P01]](https://resources.rndsystems.com/images/products/Recombinant-Human-CRBN-Protein-SDS-Page-H00051185-P01-img0002.jpg "SDS-PAGE: Recombinant Human CRBN GST (N-Term) Protein [H00051185-P01]")
Binds cereblon; also TNF-α synthesis inhibitor
| Chemical Name: | N-(2,6-dioxo-3-piperidinyl)phthalimide |
| Purity: | ≥98% |
Negative control for dTAG-13 (Cat. No. 6605)
| Chemical Name: | 1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester |
| Purity: | ≥97% |
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #978015 |
| Applications: | IHC, ICC/IF |
His10 Neddylated
| Reactivity: | Human |
| Source: | Sf 21 (baculovirus) |
| Accession #: | Q13619.3 (CUL4A); P62877.1 (RBX1); Q16531.1 (DDB1), Q96SW2.1 (CRBN) |
| Applications: | Bioactivity |
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
| Chemical Name: | 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione |
| Purity: | ≥98% |
Potent and selective Wee1 Degrader (PROTAC®)
| Chemical Name: | 4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione |
| Purity: | ≥98% |
Potent and selective cereblon Degrader (PROTAC®); cell-permeable
| Chemical Name: | (2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥96% |
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
| Chemical Name: | 4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]butanoic acid |
| Purity: | ≥95% |
Cereblon ligand with PEG linker and terminal acid for onward chemistry
| Chemical Name: | 3-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]propanoic acid |
| Purity: | ≥95% |
High affinity cereblon fluorescent probe
| Chemical Name: | 2-((1E,3E)-5-((E)-1-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium-5-sulfonate |
| Purity: | ≥90% |
Cereblon ligand with PEG linker and terminal azide for onward chemistry
| Chemical Name: | 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% |
Cereblon ligand with alkyl linker and terminal azide for onward chemistry
| Chemical Name: | 4-[(2-Azidoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% |
Cereblon ligand with terminal piperidine for onward chemistry
| Chemical Name: | 3-[1,3-Dihydro-1-oxo-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione dihydrochloride |
| Purity: | ≥94% |
Cereblon ligand with alkyl linker and terminal azide for onward chemistry
| Alternate Names: | Azido-Thalidomide |
| Chemical Name: | N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide |
| Purity: | ≥98% |
Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs
| Chemical Name: | 2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid |
| Purity: | ≥98% |
Cereblon ligand with PEG linker and terminal amine for onward chemistry
| Alternate Names: | Thalidomide - linker 1 |
| Chemical Name: | N-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride |
| Purity: | ≥95% |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | Thalidomide - linker 4 |
| Chemical Name: | 4-[(6-Aminohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥95% |
Cereblon ligand with PEG linker and terminal amine for onward chemistry
| Alternate Names: | Pomalidomide - linker 1 |
| Chemical Name: | 4-[[2-[2-(2-Aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride |
| Purity: | ≥95% |
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
| Alternate Names: | Pomalidomide - linker 3 |
| Chemical Name: | 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid |
| Purity: | ≥95% |
