Human Cyclin D3 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB6570R Datasheet / COA / SDS

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FAB6570R-100UG

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Human Cyclin D3 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Cyclin D3 in direct ELISAs. In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human (rh) Cyclin B1 and D1 is observed. No cross-reactivity with rhCyclin A1, A2, B2, C, D2, E1, or E2 is observed.

Source

Monoclonal Mouse IgG2b Clone # 588726

Purification

Protein A or G purified

Immunogen

E.coli-derived recombinant human Cyclin D3
Met1-Leu292
Accession # P30281

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Cyclin D3

Cyclin D3 is a 37 kDa cell cycle regulatory protein whose expression level and nuclear/cytoplasmic distribution are tightly regulated in synchrony with the cell cycle. Cyclin D3 complexes containing Cdk4 or Cdk6 induce phosphorylation of Rb, a requirement for progression through the G1/S cell cycle transition. Human Cyclin D3 shares 95% and 93% amino acid sequence identity with mouse and rat Cyclin D3, respectively.

Entrez Gene IDs

896 (Human)

Alternate Names

CCND3; Cyclin D3; D3-type cyclin; G1/S-specific cyclin D3; G1/S-specific cyclin-D3