Human FoxO1/FKHR Alexa Fluor™ Plus 680‑conjugated Antibody

Name: Human FoxO1/FKHR Alexa Fluor™ Plus 680‑conjugated Antibody
Brand: R&D Systems
SKU: FAB5939AFP680
Price: 549 USD
Availability: InStock

R&D Systems | Catalog # FAB5939AFP680

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Monoclonal Mouse IgG_2B Clone # 597554

View all FoxO1/FKHR Primary Antibodies »

Product Specifications

Specificity

Detects human FoxO1/FKHR in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human FoxA1 (aa 253-472), B1 (aa 191-324), C1 (aa 208-322), D3 (aa 1-140), F1 (aa 129-354), G1 (aa 283-489), J1 (aa 301-421), J3 (aa 375-552), K1 (aa 493-670), M1 (aa 642-763), O3A (aa 372-673), P1 (aa 231-420), P2 (aa 269-460), P3 (aa 179-279), or P4 (aa 229-410) is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2B

Applications for Human FoxO1/FKHR Alexa Fluor™ Plus 680‑conjugated Antibody

Application

Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: FoxO1/FKHR

FoxO1, also called FKHR (forkhead in rhabdomyosarcoma), is a 655 amino acid (aa), 70 kDa, ubiquitously expressed member of the forkhead box O family of winged helix transcription factors. In neurons, it is activated in response to stress, translocating to the nucleus where it promotes apoptosis and blocks proliferation. In insulin-responsive tissues, nutrient abundance triggers phosphorylation by AKT that blocks nuclear translocation and activity. A 60 kDa form, cleaved at R537, has been found in androgen-treated prostate cancer cells. Over aa 353-655, human FoxO1 shares 93% aa identity with mouse and rat FoxO1.

Long Name

Forkhead Box O1

Alternate Names

FKH1, FKHR

Entrez Gene IDs

2308 (Human); 56458 (Mouse); 84482 (Rat)

Gene Symbol

FOXO1

UniProt

Q12778 (Human)

Additional FoxO1/FKHR Products

Product Documents for Human FoxO1/FKHR Alexa Fluor™ Plus 680‑conjugated Antibody

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Certificate of Analysis

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Product Specific Notices for Human FoxO1/FKHR Alexa Fluor™ Plus 680‑conjugated Antibody

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only