Human GPR158 Alexa Fluor™ Plus 647‑conjugated Antibody

R&D Systems | Catalog # FAB102861AFP647

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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunocytochemistry

Label

Alexa Fluor Plus 647 (Excitation = 658 nm, Emission = 675 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 1027651
View all GPR158 Primary Antibodies »

Product Specifications

Specificity

Detects human GPR158 in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human GPR158 Alexa Fluor™ Plus 647‑conjugated Antibody

Application
Recommended Usage

Flow Cytometry

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Spectra Viewer

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Flow Cytometry

Background: GPR158

G-protein coupled receptor 158 (GPR158) is a receptor belonging to the Class C GPCR family. It lacks the extracellular Venus flytrap module characteristic of the known members of that family and instead contains two other elements that are not typical of the class: a calcium-binding EGF-like domain and a leucine repeat region (1, 2). The mature extracellular domain of human GPR158 contains 393 amino acids (aa) and shares 89% identity with both mouse and rat GPR158. GPR158 is expressed at the highest level in the brain, but also in a variety of other tissues including retina, spleen, liver and lung (3). GPR158 was originally identified in functional screens linked with biological stress and has been implicated in the osteocalcin effect on cognitive processes in the brain (4, 5), and glaucoma and cancer in the periphery (4, 6).

References

  1. Jingami, H. et al. (2003) Curr. Opin. Neurobiol. 13:271.
  2. Bjarnadóttir, T.K et al. (2005) Gene. 362:70.
  3. Orlandi, C. et al. (2012) J. Cell Biol. 197:711.
  4. Itakura, T. et al. (2019) J. Ocul. Pharmacol. Ther. 35:203.
  5. Khrimian, L. et al. (2017) J. Exp. Med. 214:2859.
  6. Fenner, A. (2015) Nat. Rev. Urol. 12:182.

Alternate Names

KIAA1136, RP11-59G22.1

Entrez Gene IDs

57512 (Human); 241263 (Mouse); 291352 (Rat)

Gene Symbol

GPR158

UniProt

Q5T848

Additional GPR158 Products

Product Documents for Human GPR158 Alexa Fluor™ Plus 647‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human GPR158 Alexa Fluor™ Plus 647‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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