Human LRP‑1 beta subunit Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB2368R Datasheet / COA / SDS

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FAB2368R-100UG

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Human LRP‑1 beta subunit Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human LRP-1 beta subunit in ELISA and Western blots.

Source

Monoclonal Mouse IgG2b Clone # 1034124

Purification

Protein A or G purified

Immunogen

E. coli-derived human LRP-1 Cluster II
Gln4449-Ala4544
Accession # Q07954

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: LRP-1B

LRP-1 (low-density lipoprotein receptor-related protein 1) is a large type I transmembrane protein belonging to the LDL receptor superfamily. The extracellular domain of LRP-1 is organized in four clusters of ligand-binding repeats that recognizes at least 30 different ligands. The amino acid sequence of human and mouse LRP-1 cluster II share 100% identity. LRP-1 is an endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. It plays a crucial role in early embryonic development.

Long Name

LDL Receptor-related Protein 1B

Entrez Gene IDs

53353 (Human); 94217 (Mouse)

Alternate Names

EC 1.1.1.94; EC 3.4.21.9; low density lipoprotein receptor related protein-deleted in tumor; low density lipoprotein receptor-related protein 1B; low density lipoprotein-related protein 1B (deleted in tumors); Low-density lipoprotein receptor-related protein-deleted in tumor; LRP1B; LRP-1B; LRP-deleted in tumors; LRPDIT; LRP-DIT; LRP-DITlow-density lipoprotein receptor-related protein 1B